Current Openings


Tarveda Therapeutics is developing potent and selective miniature conjugates for the treatment of patients with solid tumors.

Position Summary:

The Principal Scientist will work in multi-disciplinary teams in a fast paced environment to advance pre-clinical and clinical programs at Tarveda. The Principal Scientist will be responsible for the execution of internal and outsourced Drug Substance chemistry activities spanning pre-clinical research, clinical program development, and will oversee key c-GMP regulated activities from initial feasibility, technology transfer and actual Drug Substance manufacturing and batches release. A solid understanding of c-GMP regulatory law and guidance, compendia, and common industry practices in the US and EU is an advantage.

The Principal Scientist will manage process chemistry activities for key manufacturing and research vendors (CRO/CDMOs) to ensure optimal performance and timeliness of their work while building a strong business relationship.

Essential Functions:

  • Design, perform and play a leadership role in internal and external process chemistry efforts on Drug Substance R&D.
  • Collaborate with peers and effectively work in an energized, fast-paced and cross-functional results oriented R&D team environment to deliver the objectives of Tarveda in a timely and cost efficient manner that meets quality requirements.
  • Lead technical projects and lab work, spanning multiple initiatives in small-molecule process chemistry R&D and CMC support.
  • Project management and/or technical lead of c-GMP manufacturing activities at CDMOs, maintaining clear and efficient business relationships with vendors.
  • Oversight and execution of process chemistry feasibility and technology transfer activities, master batch record preparation, review and approval. Material release, OOS/OOT, deviations and investigations, etc. as required at CDMOs vendors.
  • Ratio of lab work to deskwork will vary with time. Current ratio 50/50.
  • Author SOP, methods, protocols, reports, and contribute to regulatory submissions.
  • Coordinate closely with QA/QC, Analytical Chemistry, Drug Product personnel and management to provide project updates, workflows, and timelines/budgets.
  • Some travel required (less than 10%) mainly for providing technical support at domestic and international CDMOs during API manufacturing.

Education and Experience:

  • MS or PhD in synthetic organic chemistry
  • 5+ years of CMC experience with PhD, or 8+ years with MS is required
  • Established background in process chemistry R&D and c-GMP manufacturing of Drug Substance
  • Experience with vendor management of CROs/CDMOs for Drug Substance
  • Experience working with early-phase oncology programs in humans is an advantage
  • Experience developing drug substances for Phase 1 & 2 human clinical trials in oncology
  • Deep understanding of synthetic organic chemistry, process chemistry, synthesis, purification, isolation and characterization of organic compounds and analytical methodologies common to the pharmaceutical industry
  • Lab work at times involves handling highly potent and/or cytotoxic materials: experience handling these types of compounds is preferable

Required Competencies:

  • Identify and solve complex problems
  • Team oriented (cross-functional teams)
  • Effective communicator (written and verbal)
  • Interpersonal skills
  • Detail oriented
  • Independent
  • Results oriented
  • Multi-tasking
  • Strong sense of urgency

Tarveda Therapeutics is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

Please send your resume and a brief cover letter describing why you should be considered for the position to the careers@tarveda.com

Tarveda Therapeutics, Inc., 134 Coolidge Ave., Watertown, MA 02472
Website: www.tarveda.com


Tarveda Therapeutics, Inc. is a clinical stage biotechnology company that discovers and develops Pentarins™, a new class of potent and selective miniaturized drug conjugates with enhanced targeting capabilities for the treatment of solid cancer tumors. Tarveda’s lead Pentarin drug candidate, PEN-221, is a miniaturized drug conjugate that targets the somatostatin receptor 2 (SSTR2) for treatment of patients with neuroendocrine and small cell lung cancers. PEN-221 comprises a highly selective peptide that targets SSTR2 linked to the potent cytotoxic DM1 through a cleavable linker.

Tarveda is also advancing its HSP90 drug conjugate platform with lead drug candidate PEN-866, which is a miniaturized HSP90 targeting drug conjugate that comprises a small molecule HSP90 targeting ligand conjugated to SN-38, the highly potent, active metabolite of irinotecan. Tarveda’s strategy includes developing its own proprietary Pentarins as well as applying the Pentarin platform to enhance the effectiveness of the targeting moieties and novel payloads of pharmaceutical collaborators.

Position Summary:

We are seeking an exceptional individual to hire as Scientist I in our Formulation and Analytical Chemistry group. The successful candidate will work both independently and with the group to evaluate early discovery compounds and develop formulations for preclinical and early human studies for our experimental compounds to address the specific challenges associated with drug solubility, bioavailability, and/or physical/chemical stability.

Essential Functions:

  • Develop and characterize parenteral formulations for small molecules and peptide conjugates to support non-clinical and early clinical drug development carried in-house and at CROs
  • Design and execute experiments to support novel formulations stability and characterization for in vivo testing
  • Collaborate with chemistry, process development, and biology teams to define desired formulation attributes
  • Develop analytical methods to assess drug purity, formulation stability and potency
  • Perform routine HPLC analysis for formulation stability and dose verification
  • Support Chemistry team by carrying out stability studies for new chemical entities, starting and reference materials
  • Keep abreast of research literature and apply new relevant concepts to solve challenges related to drug solubility, aggregation and chemical stability
  • Develop new and refine existing formulations of drug product for leading candidates
  • Prepare and execute study protocols, technical reports and materials specifications and maintain appropriate records
  • Actively participate in cross-functional project teams as a representative of the Formulation group

Education and Experience:

  • MS with 5+ years of experience or equivalent in Pharmaceutical Sciences, Formulation Development, and/or Analytical Development for novel oncology products
  • Hands on experience in early stages of formulation development, and characterization of parenteral products
  • Experience with key analytical methods: HPLC, Karl Fisher, and DLS
  • Expertise in formulation developments of BCS class III and IV as well as knowledge of cytotoxic materials handling and operations is a plus

Required Competencies:

  • Team oriented
  • Effective communicator (written and verbal)
  • Detail oriented
  • Independent
  • Results oriented
  • Multitasker
  • Strong sense of urgency

Tarveda Therapeutics is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

Please send your resume and a brief cover letter describing why you should be considered for the position to the careers@tarveda.com

Tarveda Therapeutics, Inc., 134 Coolidge Ave., Watertown, MA 02472
Website: www.tarveda.com


Tarveda Therapeutics, Inc. is a clinical stage biotechnology company that discovers and develops Pentarins™, a new class of potent and selective miniaturized drug conjugates with enhanced targeting capabilities for the treatment of solid cancer tumors. Tarveda’s lead Pentarin drug candidate, PEN-221, is a miniaturized drug conjugate that targets the somatostatin receptor 2 (SSTR2) for treatment of patients with neuroendocrine and small cell lung cancers. PEN-221 comprises a highly selective peptide that targets SSTR2 linked to the potent cytotoxic DM1 through a cleavable linker.

Tarveda is also advancing its HSP90 drug conjugate platform with lead drug candidate PEN-866, which is a miniaturized HSP90 targeting drug conjugate that comprises a small molecule HSP90 targeting ligand conjugated to SN-38, the highly potent, active metabolite of irinotecan. Tarveda’s strategy includes developing its own proprietary Pentarins as well as applying the Pentarin platform to enhance the effectiveness of the targeting moieties and novel payloads of pharmaceutical collaborators.

Position Summary:

The Sr. Scientist, Medicinal Chemistry will contribute to integrated research teams aimed at designing and synthesizing novel drug conjugates to target tumors.

Essential Functions:

  • Drive strategy and compound design on project teams focused on successful project progression and candidate selection
  • Synthesize conjugates in the laboratory and identify and solve challenges encountered in the synthesis of conjugates
  • Serve as a leader and key contributor for cross-disciplinary drug discovery project teams
  • Serve as a leader and key contributor for external contract chemistry teams
  • Build and maintain a broad awareness of the technological and the competitive landscape in the field of targeted drug conjugates

Education and Experience:

  • PhD. in organic chemistry with 2-5 years of experience, or M.S. in organic chemistry with 5-10 years of experience, in the biotechnology or pharmaceutical industry
  • Demonstrable deep experience and knowledge of medicinal chemistry, with a track-record of creative problem solving, and laboratory-based success in small-molecule drug discovery
  • Experience in the area of the design and synthesis of targeted drug conjugates is a plus
  • Track record of successful leadership and/or participation in cross-functional drug-discovery project teams
  • Experience in collaborating with external contract chemistry teams
  • Outstanding oral and written communication skills
  • Ability to foster teamwork and collaboration with colleagues throughout the organization

Required Competencies:

  • Team oriented
  • Effective communicator (written and verbal)
  • Detail oriented
  • Independent
  • Results oriented
  • Multi-tasking
  • Strong sense of urgency

Tarveda Therapeutics is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

Please send your resume and a brief cover letter describing why you should be considered for the position to the careers@tarveda.com

Tarveda Therapeutics, Inc., 134 Coolidge Ave., Watertown, MA 02472
Website: www.tarveda.com